Journal article
Do variants in GSTs modify the association between traffic air pollution and asthma in adolescence?
G Bowatte, CJ Lodge, AJ Lowe, B Erbas, M Dennekamp, GB Marks, J Perret, J Hui, M Wjst, LC Gurrin, KJ Allen, MJ Abramson, MC Matheson, SC Dharmage
International Journal of Molecular Sciences | MDPI AG | Published : 2016
DOI: 10.3390/ijms17040485
Abstract
Polymorphisms in genes involved in the oxidative stress response may partially explain the documented heterogeneous associations between traffic-related air pollution (TRAP) exposure and asthma and allergies in children. We investigated whether the GSTT1, GSTM1 and GSTP1 gene polymorphisms modified the associations between TRAP exposure during the first year of life and asthma, wheeze and hay fever in adolescence. We used a birth cohort of 620 high risk infants from the Melbourne Atopy Cohort Study. TRAP exposure during the first year of life was defined as the cumulative length of major roads within 150 m of each participant’s residence during the first year of life. Wheeze, asthma and hay ..
View full abstractGrants
Funding Acknowledgements
Gayan Bowatte and Jennifer Perret are supported by the Centre for Air Quality and Health Research and Evaluation (CAR)-a National Health & Medical Research Council (NHMRC) Centre of Research Excellence. Caroline J. Lodge, Adrian J. Lowe, Melanie Matheson and Shyamali Dharmage are supported by the NHMRC.